Tiotropium Bromide EP Impurity A Sodium Dihydrate CAS 877467-46-4(Anhydrous CAS)
| CAS No. | 877467-46-4(Anhydrous CAS) |
| Molecular Formula | C10H7O3S2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Tiotropium Bromide EP Impurity A Sodium Dihydrate (CAS 877467-46-4(Anhydrous CAS)) is a certified pharmaceutical impurity reference standard with the molecular formula C10H7O3S2NaH2O and a molecular weight of 280.29 g/mol.
Structurally, Tiotropium Bromide EP Impurity A Sodium Dihydrate (C10H7O3S2NaH2O) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.5, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 280.29 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C10H7O3S2 Na 2*H2O |
| Molecular Weight | 280.29 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Sulfur Atoms | 2 |
Related Tiotropium Standards
- Tiotropium Impurity 26 (CAS 10299-90-8)
- Tiotropium Bromide Impurity 8 Potassium Salt (CAS 10304-09-3)
- Tiotropium Bromide EP Impurity H (Mixture of Enantiomers) (CAS 1044148-31-3)
- Tiotropium Bromide EP Impurity H-d3 Bromide (Mixture of Enantiomers) (CAS 1044148-31-3（unlabeled）)
- Tiotropium-d6 (CAS 1126775-44-7)
- Tiotropium-D3 Bromide (CAS 1127226-56-5)
- Tiotropium Bromide EP Impurity B (CAS 136310-64-0)
- Tiotropium EP Impurity D (CAS 136310-66-2)
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- 2,3-Dimethyl-Imidazo[1,2-A]Pyridin-8-Ylamine (CAS 119858-51-4)
- ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) distearate (CAS 142-20-1)
- 75560-39-3 Ethyl-1-13C iodide Iodoethane-1-13C (CAS 75560-39-3)
- 3,5-Difluoro-2-(hexyloxy)benzaldehyde (CAS 1443343-83-6)
- Glucagon-like peptide 2 (CAS 89750-15-2)
- Pancreatic Polypeptide (31-36) Free Acid, human (CAS 192432-73-8)
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